Renatrel Tablet 0.075 mg

৳ 1.43

Renata Limited

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Description

Norgestrel

Indications

Norgestrel in combination with ethinyl estradiol is indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception.

Therapeutic Class

Emergency Contraceptive Pill, Oral Contraceptive preparations

Pharmacology

Norgestrel (and more specifically the active stereoisomer levonorgestrel) binds to the progesterone and estrogen receptors within the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. Loss of the LH surge inhibits ovulation and thereby prevents pregnancy.

Dosage & Administration

0.075 mg at same time each day

Contraindications

  • Documented hypersensitivity
  • Active or history of breast cancer
  • Arterial thromboembolic disease (stroke, MI), thrombophlebitis, DVT/PE, thrombogenic valvular disease
  • Estrogen-dependent neoplasia
  • Liver disease, liver tumors
  • Undiagnosed abnormal vaginal bleeding
  • Uncontrolled hypertension
  • Diabetes mellitus with vascular involvement
  • Jaundice with prior oral contraceptive use, pregnancy, smoking >15 cigarettes/d) and >35 yo, history of migraine with aura
  • Pregnancy or use as a diagnostic test for pregnancy

Side Effects

Edema, Weakness, Anorexia, Amenorrhea, Breakthrough bleeding, Change in menstrual flow, Spotting

Pregnancy & Lactation

Pregnancy Category: X
Lactation: unsafe

Precautions

  • Documented hypersensitivity
  • Active or history of breast cancer
  • Thrombophlebitis, DVT/PE, thrombogenic valvular disease
  • Estrogen-dependent neoplasia
  • Liver disease, liver tumors
  • Undiagnosed abnormal vaginal bleeding, uncontrolled hypertension, diabetes mellitus with vascular involvement, jaundice with prior oral contraceptive use, pregnancy, smoking >15 cigarettes/d) and >35 yo, history of migraine w/ aura
  • Serum levels near baseline 24 hr after ingestion, so rigid adherence to dosing schedule is essential for efficacy
  • DM, asthma, cardiac dysfunction, irregular menstrual bleeding patterns, bone mineral density changes, depression, epilepsy, migraine, renal dysfunction
  • Risk of ectopic pregnancy is 0.5%

Storage Conditions

Should be stored in cool and dry place
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