Tenoren Tablet 100 mg

৳ 1.38

ACI Limited

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Description

Atenolol

Indications

Atenolol is indicated for: Hypertension, Angina pectoris, Cardiac arrhythmia, Myocardial infarction

Therapeutic Class

Beta-adrenoceptor blocking drugs, Beta-blockers

Pharmacology

The synthesis of atenolol resulted from attempts to produce a β-adrenoceptor antagonist that would competitively block β1 (cardiac) receptors but have no effect on β2-receptors. It is classified as a β1 selective (cardioselective) β-adrenergic receptor antagonist with no membranestability activity and no partial agonist activity. It is markedly the most hydrophilic of the currently available β- blockers and thus penetrates the lipid of cell membranes poorly

Dosage & Administration

Hypertension: 50 mg once daily, the daily dose can be raised to 100 to 200 mg.

Angina pectoris: 50 to 100 mg daily.

Cardiac arrhythmia: Atenolol in low dose, 25-50 mg once daily, can be used in combination with digoxin to control the ventricular rate in atrial fibration or atrial flutter which is refractory to digoxin alone.

Interaction

Catecholamine-depleting drugs (e.g., Reserpine) and Calcium channel blockers may have an additive effect when given with Atenolol. Clonidine and aspirin may have some drug reactions.

Contraindications

Atenolol is contraindicated for: Second and third degree heart block, Untreated heart failure, Overt cardiac failure, Cardiogenic shock

Side Effects

In general, atenolol is well tolerated although in a small number of patients (approximately 2-3%) therapy must be withdrawn because of troublesome symptomatic adverse effects. The commonest of these are cold extrimities, fatigue, vivid dreams, insomnia, diarrhoea, constipation, impotence and paraesthesia. Bronchospasm has been occurred with atenolol although this is very much less common than with the non-selective β-blockers.

Pregnancy & Lactation

Pregnancy Category D. Caution should be exercised when Atenolol is administered to a nursing woman.

Precautions

Patients already on a β-blocker must be evaluated carefully before Atenolol is administered. Atenolol may aggravate peripheral arterial circulatory disorders.

Impaired Renal Function: Caution should be excised.

Overdose Effects

Overdosage with Atenolol has been reported with patients surviving acute doses as high as 5 gm. One death was reported in a man who may have taken as much as 10 gm acutely.

Use in Special Population

Safety and effectiveness in pediatric patients have not been established.
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